Sunday, 6 April 2008

Breast Calcifications in Ehlers-Danlos Syndrome

Laxmi Radhakrishnan, Walid D. Salman, Alec J. Howat
The Breast Journal Volume 14 Issue 2 Page 196-197, March/April 2008

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A 52-year-old Caucasian woman with Ehlers–Danlos syndrome (EDS) presented for mammography as part of the NHS Breast Screening Programme. A focus of dense calcifications was seen in the left breast. Core biopsy showed stromal calcification. The patient insisted on removal of the abnormal area. The wide local excision showed stromal calcification identical to that seen in the core biopsy. Clinicians should be aware of EDS patients presenting with breast stromal calcifications and this fact should be taken into account when investigating such lesions.

Computed Tomography-Guided Localization of Breast Lesions

Salvatore Murgo, Hedwige Wyshoff, Daniel Faverly, Kurt Crener, Louisiane Lenaerts
The Breast Journal Volume 14 Issue 2 Page 169-175, March/April 2008

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Magnetic resonance (MR) imaging and computed tomography (CT) of the breast allow the detection of breast lesions occult on physical examination, mammography and ultrasound. We report our experience to localize such lesions under CT-guidance.

All the lesions were localized with success under CT-guidance. The pathological analysis of the surgical specimens concluded in 11 breast cancers, four lesions of uncertain malignancy potential and 15 benign lesions. The size of these lesions ranged from 4 to 28 mm (mean: 10 mm). No significant complication related to the procedure was observed. Localization under CT guidance is a safe and effective technique to guide the surgical biopsy of breast lesions that can be seen solely on MR or CT.

A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization

Jenevieve H. Hughes, Mark C. Mason, Richard J. Gray, Sarah A. McLaughlin, Amy C. Degnim, Jack T. Fulmer, Barbara A. Pockaj, Patricia J. Karstaedt, Michael C. Roarke
The Breast Journal Volume 14 Issue 2 Page 153-157, March/April 2008

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This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions.

RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.

Significance of Intramammary Lymph Nodes in the Staging of Breast Cancer: Correlation with Tumor Characteristics and Outcome

Aziza Nassar, Cynthia Cohen, George Cotsonis, Grant Carlson
The Breast Journal Volume 14 Issue 2 Page 147-152, March/April 2008

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Patients with stage I breast carcinoma and positive intraMLN metastases have been reported to have a poorer prognosis compared to patients with similar stage and negative intraMLN metastases. However, the presence of intraMLN metastases does not appear to influence the survival of patients with stage II breast carcinoma.

IntraMLN metastasis is a poor prognostic marker but not an independent predictor of poor outcome in patients with breast carcinoma.

Fibroadenoma with Digital Fibroma-Like Inclusions in Neurilemmoma-Like Stromal Component

Karol Kajo, Katarina Machalekova
The Breast Journal Volume 14 Issue 1 Page 112-113, January/February 2008

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An Unusual Case of Fibromatosis of the Axilla

Robert H. Caulfield, Atoussa Maleki-Tabrizi, Jeremy Birch, John Davies, Paul Sauven, Venkat Ramakrishnan
The Breast Journal Volume 14 Issue 1 Page 110-112, January/February 2008

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Synchronous Primary Breast Osteosarcoma and Contralateral Benign Cystosarcoma Phylloides: Radiologic and Pathologic Imaging

Aytug Uner, Banu Ozturk, Mustafa Benekli, Ugur Coskun, Savas Kocak, Ali Osman Kaya, Diclehan Unsal, Selim Erekul, Emel Yaman, Ramazan Yildiz, Suleyman Buyukberber
The Breast Journal Volume 14 Issue 1 Page 109-110, January/February 2008

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Metastatic Breast Cancer Mimicking Benign Fatty Liver Infiltration

Steve R. Martinez, Rosalie J. Hagge, Scott D. Christensen, John M. Webb
The Breast Journal Volume 14 Issue 1 Page 108-108, January/February 2008

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Desmoid Tumor of the Breast: Radiologic Appearance with a Focus on its Magnetic Resonance Features

Linda Anna, Londero Viviana, Bazzocchi Massimo, Zuiani Chiara
The Breast Journal Volume 14 Issue 1 Page 106-107, January/February 2008

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Mammographic Screening in Women at Increased Risk of Breast Cancer after Treatment of Hodgkin's Disease

Ava Kwong, Steven L. Hancock, Joan R. Bloom, Sunita Pal, Robyn L. Birdwell, Carol Mariscal, Debra M. Ikeda
The Breast Journal Volume 14 Issue 1 Page 39-48, January/February 2008

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Treatment regimens for Hodgkin’s disease (HD) that have included radiation to lymph node regions in the thorax have contributed to high rates of long-term disease-free survival. However, incidental radiation exposure of breast tissue in young women has significantly increased the risk of breast cancer compared to expected rates in the general population. After informing patients about risks associated with previous treatment of HD, we studied screening mammograms and call-back rates in women at increased risk for developing breast cancer at a younger age.

Women who have had thoracic nodal irradiation for Hodgkin’s disease have an increased risk of developing secondary breast cancer at an unusually young age. As expected in younger women, high density breast tissue was common on mammography, and the recall and biopsy rates were unusually high. However, early mammographic screening facilitated diagnosis of in situ and early invasive cancer in 3.5% of our subjects.