Fiberoptic Ductoscopy-Guided Intraductal Biopsy Improve the Diagnosis of Nipple Discharge

Fiberoptic Ductoscopy-Guided Intraductal Biopsy Improve the Diagnosis of Nipple Discharge
Hong Ling, Guang-yu Liu, Jin-song Lu, Susan Love, Jia-xin Zhang, Xiao-li Xu, Wei-ping Xu, Kun-wei Shen, Zhen-zhou Shen, Zhi-min Shao
The Breast Journal 15 ( 2): 168 - 175

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Fiberoptic ductoscopy (FDS)-guided intraductal biopsy is a minimally invasive technique developed to obtain pathologic diagnoses for patients with spontaneous nipple discharge.

We performed biopsies of 53 intraductal lesions from March 2006 to April 2007 followed by surgical microdochectomy. FDS-guided intraductal biopsy was shown to be a minimally invasive, safe, and convenient technique with a high ability (90.6%) to get adequate samples. Twenty-seven solitary papillomas, 12 multiple intraductal papilloma, five ductal hyperplasia, three ductal carcinoma in situ, and one invasive ductal carcinoma were diagnosed.

Compared with conventional microdochectomy, FDS-guided intraductal biopsy can significantly increase the detection rate of solitary papilloma (40.7% versus 92.6%, p <>

Fiberoptic Ductoscopy-Guided Intraductal Biopsy Improve the Diagnosis of Nipple Discharge
Hong Ling, Guang-yu Liu, Jin-song Lu, Susan Love, Jia-xin Zhang, Xiao-li Xu, Wei-ping Xu, Kun-wei Shen, Zhen-zhou Shen, Zhi-min Shao
The Breast Journal, Volume 15 Number 2, 2009 168–175

Link to Journal

Fiberoptic ductoscopy (FDS)-guided intraductal biopsy is a minimally invasive technique developed to obtain pathologic diagnoses for patients with spontaneous nipple discharge.

We performed biopsies of 53 intraductal lesions from March 2006 to April 2007 followed by surgical microdochectomy. FDS-guided intraductal biopsy was shown to be a minimally invasive, safe, and convenient technique with a high ability (90.6%) to get adequate samples. Twenty-seven solitary papillomas, 12 multiple intraductal papilloma, five ductal hyperplasia, three ductal carcinoma in situ, and one invasive ductal carcinoma were diagnosed.

Compared with conventional microdochectomy, FDS-guided intraductal biopsy can significantly increase the detection rate of solitary papilloma (40.7% versus 92.6%, p < 0.05). It should be a routine procedure after intraductal lesion found by screening FDS.

Since it would underestimate all multiple intraductal papilloma and some (50%) cancer, microdochectomy is inevitable if biopsies show atypical ductal hyperplasia

Early Detection of Breast Cancer through Population-Based Mammographic Screening in Asian Women: A Comparison Study between Screen-Detected and Sympto

Early Detection of Breast Cancer through Population-Based Mammographic Screening in Asian Women: A Comparison Study between Screen-Detected and Symptomatic Breast Cancers
Esther W. L. Chuwa, Allen W. Y. Yeo, Heng Nung Koong, Chow Yin Wong, Wei Sean Yong, Puay Hoon Tan, Juliana T. S. Ho, Jill S. L. Wong, Gay Hui Ho
The Breast Journal, Volume 15 Number 2, 2009 133–139

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Screening mammography has allowed the detection of smaller and hence oncologically more favorable lesions in Asian women. Although no significant survival benefit was demonstrated in our study, a longer period of follow-up is essential before the benefit of mortality reduction, as a result of mammography screening becomes evident in our population

Breast MRI in a Case of "Early Onset" Lactating Adenoma

Breast MRI in a Case of "Early Onset" Lactating Adenoma
Stefano Magno, Daniela Terribile, Gianluca Franceschini, Cristina Fabbri, Pierfrancesco D'Alba, Federica Chiesa, Alba Di Leone, Melania Costantini, Paolo Belli, Riccardo Masetti
The Breast Journal, Volume 15 Number 1, 2009 105–106

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Care report with images

The Importance of Preoperative Breast MRI for Patients Newly Diagnosed with Breast Cancer

The Importance of Preoperative Breast MRI for Patients Newly Diagnosed with Breast Cancer
Joseph P. Crowe, Rebecca J. Patrick, Alice Rim
The Breast Journal, Volume 15 Number 1, 2009 52–60

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The findings here of one community hospital's experience (13% upgrade to mastectomy rate) conflict with the COMICE Trial results

MRI and 1H MRS of The Breast: Presence of a Choline Peak as Malignancy Marker is Related to k21 Value of the Tumor in Patients with Invasive Ductal Carcinoma
Patricia R. Geraghty, Maurice A.A.J. van den Bosch, Daniel M. Spielman, Sandeep Hunjan, Robyn L. Birdwell, Katherine J. Fong, Lara A. Stables, Marowan Zakhour, Robert J. Herfkens, Debra M. Ikeda
The Breast Journal, Volume 14 Number 6, 2008 574–580

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Paper from my Stanford colleague, Deb Ikeda, showing that false -ve scans can occur in invasive ductal carcinoma and that the presence of a choline peak on 1H MRS as malignancy marker is related to the k21 value of the invasive tumor being imaged

Predictors to Assess Non-Sentinel Lymph Node Status in Breast Cancer Patients with Sentinel Lymph Node Metastasis
Hiromitsu Jinno, Michio Sakata, Sota Asaga, Masahiro Wada, Toshiyuki Shimada, Yuko Kitagawa, Takayuki Suzuki, Tadaki Nakahara, Naoto Kitamura, Atsushi Kubo, Makio Mukai, Tadashi Ikeda, Masaki Kitajima
The Breast Journal, Volume 14 Number 6, 2008 551–555

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Lymphatic invasion of the primary tumor and the number of tumor-involved sentinel lymph nodes (SLN) were significantly correlated with non-SLN metastasis. These 2 factors could be used together to select a sub-group of patients who may not benefit from complete ALND despite a positive SLNB